Therapeutic potential of palmitoylethanolamide in neurodegenerative diseases

Isabela Petrone Arifa and Lucas Daniel Udovin

SAP Health and Policy, 2024

Abstract: The therapeutic potential of palmitoylethanolamide (PEA) in the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's. He described how PEA, an endogenous compound with anti-inflammatory and neuroprotective properties, acted on neuroinflammation and oxidative stress by activating the PPAR-α receptor. Preclinical and clinical studies were reviewed that showed cognitive and motor improvements after administration, as well as its combination with luteolin to enhance its effect. The need for further research into other diseases such as amyotrophic lateral sclerosis and frontotemporal dementia was also highlighted, emphasising the importance of rigorous methodologies to validate its efficacy.

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:cwf:shpart:shp2024140

DOI: 10.56294/shp2024140

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