Acute and Chronic Complications of High-Dose Corticosteroid Use in Patients with Spinal Shock: Systematic Revision

Bruno Fogo and Mauro Perugino
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Bruno Fogo: Universidad Abierta Interamericana, Facultad de Medicina y Ciencias de la Salud, Carrera de Medicina. Ciudad Autónoma de Buenos Aires, Argentina
Mauro Perugino: Universidad Abierta Interamericana, Facultad de Medicina y Ciencias de la Salud, Carrera de Medicina. Ciudad Autónoma de Buenos Aires, Argentina

International Journal of Neurology, 2025, vol. 59, 233

Abstract: Background: During The use of methylprednisolone (MP) in patients with acute spinal cord injury has been widely debated due to its potential neurological benefits and associated risks of complications. While the administration of MP in the early hours following the injury has been adopted in many protocols, its use during surgical procedures remains controversial because of the high incidence of adverse effects. Materials and Methods: A systematic review of studies evaluating the use of MP during surgery in patients with acute spinal cord injury was conducted. The search included databases such as PubMed and the Cochrane Library, utilizing MeSH terms such as "methylprednisolone", "spinal cord injury", and "surgical complications". The selected studies included retrospective cohorts and controlled clinical trials. Results: The reviewed studies showed an increase in the incidence of severe complications, such as respiratory infections, gastrointestinal bleeding, and sepsis, in patients treated with methylprednisolone (MP) during surgical procedures. Some studies reported short-term motor improvements, but these were not consistent over the long term. Overall, patients receiving MP were at higher risk for complications like deep vein thrombosis and pneumonia compared to those who did not receive the drug (p

Keywords: "Corticosteroids"; "Spinal Shock"; "Complications"; " Methylprednisolone"; "Randomized Controlled Trials" (search for similar items in EconPapers)
Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:cwh:ijneur:v:59:y:2025:id:233

DOI: 10.62486/ijn2025233

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