Association of the rs4988235(C) Polymorphism, a Determinant of Lactose Intolerance, with Genetic Ancestry in Latin American Populations

Sergio V. Flores, Román M. Montaña, Angel Roco-Videla and Marcela Caviedes-Olmos

Data and Metadata, 2024, vol. 3, .354

Abstract: Introduction: the rs4988235(C) polymorphism is associated with lactose intolerance and exhibits heterogeneity among populations. In Europe, the T allele (lactose tolerance) is prevalent in the north, while the C allele (lactose intolerance) is common in Asia and Africa. Methods: genotypes for rs4988235 were obtained from the 1000 Genomes Project database, selecting Latin American samples (Colombians, Mexican Americans, Peruvians, and Puerto Ricans). A total of 446 ancestry-informative markers (AIMs) were used to estimate genetic ancestry proportions. Shapiro-Wilks tests were conducted, and due to non-normality, non-parametric Kruskal-Wallis and post hoc Wilcoxon tests were applied. Results: the Shapiro-Wilks test indicated significant deviations from normality for Native-American (statistic=0.8787, p

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:dbk:datame:v:3:y:2024:i::p:.354:id:1056294dm2024354

DOI: 10.56294/dm2024.354

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