Old title: A Clinical Study on the Use of EGF-CMC Hydrogel in Minimizing Biofilm Formation in Diabetic Wounds

Dadarao Wagh, Hn, Mangaraj, Ganjoo, Kapoor and Nagpal

Health Leadership and Quality of Life, 2025, vol. 4, 622

Abstract: Introduction: Diabetes-related wounds are worsened by slowed healing and heightened bio-film formation vulnerability, which can result in chronic infections. Epidermal growth factor (EGF) is well known for having regenerating qualities, therefore adding the carboxy-methyl cellulose (CMC) were the hydro gel in preventing the growth of bio films in wounds caused by diabetes. Methods: A 13-week placebo-controlled clinical research with 30 type 2 diabetes patients (17 using CMC hydrogel, 13 using EGF-CMC hydrogel) assessed wound healing in venous ulcers. Swab samples were taken at weeks 2, 7, and 13. Microbiologists and imaging techniques analyzed biofilm formation, microbial load, strain identification, and pathogenic gene expression. Result: Comparing the EGF-CMC a hydrogel to the untreated category, a significant reduction in bio film formation was observed. Reduced numbers of microbes were found by microbiology examination and imaging procedures verified the reduction of the bio film formations. This emerged that the likelihood of separating organisms that produce bio films of injuries given CMC hydrogel formulation were eighty-three percent higher than that from injuries handled with EGF-CMC. Conclusion: The research indicates that isolates with decreased formation of bio film were seen in lesions that received EGF-CMC hydrogel, which is despite the fact of no discernible differences in bacterium counts or genes related to virulence could be identified. This result emphasizes how the reactive covering can affect the bacteria activity in diabetes patients' persistent injuries.

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:dbk:health:v:4:y:2025:i::p:622:id:622

DOI: 10.56294/hl2025622

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