Analysis of the Effectiveness and Safety of the Fentermine and Topiramate Association in Obesity: A Systematic Review of the Literature

Juan José Izquierdo Miranda and Marcelo Adrián Estrín

Multidisciplinar (Montevideo), 2025, vol. 3, 55

Abstract: Introduction: obesity is a chronic disease that can manifest itself at any stage of life, with an increasing incidence and prevalence, which contributes to other health problems. Objective: to determine the application of Phentermine and Topiramate in the treatment of obesity. Methods: a search for clinical trials and randomized controlled trials was conducted. The search was carried out exhaustively in the search engines/databases PubMed, Cachrane Library, Scopus, Google Scholar and Web of Science. Results: 21 studies were identified, of which 11 met the inclusion criteria. The evaluated research articles provided moderate evidence that the combination of Phentermine and Topiramate is effective and safe for the treatment of obesity. A gradual decrease in patients' body weight was observed from the start of treatment and up to 20 weeks thereafter. In addition, notable secondary outcomes, such as changes in blood pressure, triglyceride levels, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol and glycosylated hemoglobin (A1C) were found from the start of treatment. Conclusion: the doses of these drugs for chronic weight control in adults are 3,75 mg, 7,5 mg and 15 mg in the case of phentermine and 23 mg, 46 mg and 92 mg of topiramate, being the maximum recommended dose 15 mg/92 mg. If a 5 % weight loss is not achieved after 12 weeks with this dose, their use should be reconsidered

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:dbk:multid:v:3:y:2025:i::p:55:id:1062486agmu202555

DOI: 10.62486/agmu202555

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