Cognitive impact of chronic opioid use: A systematic review

Lara Macedo Soares and Marcelo Adrián Estrin

SCT Proceedings in Interdisciplinary Insights and Innovations, 2023, vol. 1, 10.56294/piii2023151

Abstract: The impact of chronic opioid use has been linked to a wide range of cognitive disorders, ranging from minor deficits in cognitive abilities such as attention, learning, memory and executive functions. The objective of this work is to carry out a systematic review to investigate the cognitive impact in patients who chronically use opioids and to evaluate the severity of this impact. Randomized clinical trials, case-control studies, prospective and retrospective cohorts werw evaluated in two databases: PubMed and Cochrane Central. The search in english, spanish and portuguese languages of stududies carried out in adult humans an chronic use of opioids and their cognitive impact. 7 studies were selected, 5 of wich the patients used Tramadol and the negative cognitive impact was verified, 1 study with the use of Tapentadol with a positive impact on cognition and 1 study with the use of Hydrocodone with a positive impact on neurocognition of the patients. (In conclusion, despite the limitations found here, we consider that tramadol has a negative impact on neurocognition, which does not occur in relation to tapentadol and hydrocodone, which presents an improvement in the quality of life and cognition of patients

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:dbk:procee:v:1:y:2023:i::p:1056294piii2023151:id:1056294piii2023151

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