Impact of diclofenac use on the incidence and severity of ischemic colitis: A systematic rewiew

Luciano Josué Loyola Bolognesi and Marcelo Adrián Estrin

SCT Proceedings in Interdisciplinary Insights and Innovations, 2024, vol. 2, 10.56294/piii2024335

Abstract: Introduction: ischemic colitis is an inflammation of the colon caused by reduced blood flow, and represents the most common form of intestinal ischemia. Symptoms can range from mild discomfort to severe complications such as intestinal perforation. Diclofenac, a commonly used non-steroidal anti-inflammatory drug (NSAID), is associated with gastrointestinal complications, and recent studies suggest a possible link between its use and ischemic colitis. to evaluate the impact of diclofenac use on the incidence and severity of ischemic colitis through a systematic review of the scientific literature. a search was carried out in PubMed and SciELO databases using key terms such as “Colitis”, “Ischemia”, “Diclofenac”, “Colon” and “Anti-Inflammatory Agents, Non-Steroidal”. Observational studies, clinical trials, and case reports addressing the relationship between diclofenac and ischemic colitis were included. Data were analyzed to determine the incidence and severity of colitis in patients treated with diclofenac. The studies reviewed indicated a significant relationship between the use of diclofenac and the occurrence of ischemic colitis. Cases of diclofenac-induced acute colitis were described. Other studies identified a correlation between NSAID use and recent diagnosis of ischemic colitis, possibly related to prostaglandin inhibition, which affects intestinal perfusion. diclofenac use may increase the risk of ischemic colitis. It is crucial that physicians evaluate therapeutic alternatives with lower risk and monitor patients with predisposing factors. Further research is needed to confirm a causal relationship and develop preventive strategies

Date: 2024
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