Correlation between TI-RADS classification, fine needle aspiration biopsy and paraffin biopsy in the diagnosis of thyroid nodular disease

Danyar Liset Jimenez Fajardo, Luis Alberto Rojas Ampudia, Marta Amada Oriolo Estrada, Rolando Piñero Prieto and Laura Cayarga Piñero

SCT Proceedings in Interdisciplinary Insights and Innovations, 2025, vol. 3, 10.56294/piii2025373

Abstract: Introduction: nodular thyroid disease requires invasive and non-invasive means of diagnosis, the former being the gold standard. to determine the existence of correlation between the results of the TI-RADS and Bethesda classifications and paraffin biopsy in patients with nodular thyroid disease treated at the Hospital General Docente ‘Abel Santamaría Cuadrado’ between 2019 and 2022. Methodological design: an observational, analytical and cross-sectional study was conducted. The universe consisted of 202 patients according to inclusion criteria. To test the effectiveness of the procedures, sensitivity and specificity were evaluated. To determine the agreement between variables, Cohen's kappa was studied. 63 patients were studied, with a mean age of 50.11 ± 15.71 years and predominantly female (82.5 %). Benign nodular disease was identified by biopsy in 73 % of patients. Inter-instrument agreement was Kappa=0.733 (good agreement) between TI-RADS and biopsy, Kappa=0.374 (poor agreement) between Bethesda and biopsy and Kappa=0.445 (moderate agreement) between TI-RADS and Bethesda. The sensitivity of TI-RADS was 88.2 % and specificity 89.1 % and of Bethesda sensitivity 94.1 % and specificity 55.6 %. There was good agreement between TI-RADS and paraffin biopsy, poor agreement between fine needle aspiration biopsy and paraffin biopsy and moderate agreement between TI-RADS classification and fine needle aspiration biopsy

Date: 2025
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