Impact of early administration of antibiotics in patients with sepsis and its prognoses

Lucas De Nicola Do Nascimento and Fernando Lipovestky

SCT Proceedings in Interdisciplinary Insights and Innovations, 2025, vol. 3, 10.56294/piii2025514

Abstract: Sepsis is a very complex medical condition resulting from a dysregulated inflammatory response of the host to an infectious condition, which can lead to organ dysfunction and, in the most critical cases, death. Early administration of antibiotics is crucial to improve clinical outcomes in patients with sepsis. This study aims to evaluate the impact of early administration on clinical outcomes in patients with sepsis. The objective is to evaluate the impact of early administration of antibiotics on clinical outcomes in patients with sepsis, including mortality, length of hospital stay, and complications. Data collection was performed through a search in online database such as: Pubmed, SCIELO, Google Scholar among others. The research will be composed of published and updated literatures showing the importance of early administration of antibiotics for the treatment of sepsis. The review of studies suggests a strong association between delays in antibiotic administration and increased in-hospital mortality in patients with sepsis. In the first study, it was observed that even administration within six hours showed an increasing risk of mortality with each hour of delay, this risk being particularly high in cases of septic shock. The second study confirmed this trend, with a median time to antibiotic administration of 2.1 hours. Mortality increased in proportion to the length of delay, with higher mortality rates in patients with septic shock compared to those with moderate sepsis. Each additional hour was associated with a marked increase in complications, highlighting the importance of immediate interventions to improve prognosis and reduce associated mortality. In summary, the studies reviewed show that early administration of antibiotics is a key factor in improving clinical outcomes in sepsis, especially in severe cases. The establishment of clinical practices and guidelines that prioritize rapid intervention in patients with sepsis could contribute significantly to reducing mortality and complications associated with sepsis, that is, training health care personnel to identify probable cases of sepsis and septic shock in order to act quickly in the administration of antibiotics.

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:dbk:procee:v:3:y:2025:i::p:1056294piii2025514:id:1056294piii2025514

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