SIBO: Diagnosis and interpretation of exhaled air test results

Michelle Jésica Saín and Diego Balcarce

SCT Proceedings in Interdisciplinary Insights and Innovations, 2025, vol. 3, 10.56294/piii2025551

Abstract: Small intestinal bacterial overgrowth (SIBO) has emerged as a gastrointestinal disorder of significant clinical significance. This systematic review is based on informing health professionals about the advantages and limitations of diagnostic methods, especially to make a correct interpretation of the exhaled air test, so as not to carry out unnecessary or erroneous treatment. 13 articles published in Pudmed, SEGHN, from April 2007 to 2024, on SIBO were analyzed. Jejunal aspiration and biopsy is the gold standard for the diagnosis of SIBO, with high specificity and a threshold greater than or equal to 103 colony-forming units per milliliter. Hydrogen and methane testing are the most commonly used diagnostic methods for SIBO. Glucose and lactulose are effective substrates for detecting SIBO, with glucose presenting high specificity and with lactulose greater sensitivity. The most commonly used method to diagnose SIBO is the exhaled air test because it is non-invasive and accessible.

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:dbk:procee:v:3:y:2025:i::p:1056294piii2025551:id:1056294piii2025551

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