Systematic review: Microbiota And Chronic Inflammatory Diseases In Young Adults

Emanuel Zenon Aviza Joaquín and Daniel Nestor Chiacchiara

SCT Proceedings in Interdisciplinary Insights and Innovations, 2025, vol. 3, 10.56294/piii2025579

Abstract: Introduction: The gut microbiota plays a pivotal role in human health, influencing digestion, vitamin synthesis, and immune regulation. Dysbiosis, or microbiota imbalance, is linked to chronic inflammatory diseases (CIDs), such as Crohn's disease and ulcerative colitis. Factors including genetics, environmental influences, and high-fat Western diets contribute to the prevalence of these conditions, particularly among young adults (18–35 years) in Argentina. This study aims to examine the relationship between gut microbiota and CIDs in young adults in Argentina. It seeks to identify risk factors and dysbiosis patterns by: ●Characterizing microbial composition, ●Identifying dietary and environmental influences, ●Correlating dysbiosis with inflammation and symptom severity, and ●Proposing therapeutic interventions. This systematic review follows the PRISMA methodology. ●Population: Young adults with CIDs reported in studies from 2015 to 2024. ●Variables: Microbiota composition, inflammatory markers, dietary and environmental factors, and probiotic use. ●Analysis: Data will be extracted and visualized through graphs and tables, with an assessment of the quality of selected studies. The study aims to identify dysbiosis patterns and their association with environmental factors. It will also evaluate the effectiveness of probiotic interventions in improving symptoms and enhancing the quality of life for CID patients. This research underscores the significance of gut microbiota as both a diagnostic and therapeutic tool. It aims to propose personalized strategies that could be incorporated into public health policies to mitigate the impact of CIDs.

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:dbk:procee:v:3:y:2025:i::p:1056294piii2025579:id:1056294piii2025579

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