Effects of testosterone and physical exercise on muscle mass increase and fat tissue reduction: systematic review

Ruan Franck Henriques Duque and José Vicente Postorivo Nauman

Rehabilitation and Sports Medicine, 2024, vol. 4, 91

Abstract: Introduction: in this systematic review, the authors have examined the effects of physical exercise on serum testosterone levels. Due to the differing ages and physical conditions of the individuals studied and the various protocols used, the results obtained are highly controversial. Nevertheless, it is noteworthy that there is a significant increase in plasma testosterone levels when exercises of submaximal and maximal intensity are performed. Conversely, a significant decrease in this hormone occurs when exercise is prolonged to exhaustion, both in young and adult individuals, being more pronounced in those better conditioned. Objectives: to investigate the potential effects of testosterone treatment in combination with physical exercise in achieving an increase in muscle mass volume and tissue loss. Methods: s systematic review of the literature was conducted using PubMed/Medline, SciELO, SCALE, and Google Scholar databases from inception to October 2023. Clinical trials were sought using keywords related to testosterone, BMI, and steroids. This review included clinical studies whose primary objective is to investigate the potential effects of testosterone treatment in combination with physical exercise for gaining muscle mass volume and tissue loss. Results: exercise of submaximal and maximal intensity consistently increased plasma testosterone levels, while prolonged exercise leading to exhaustion showed a significant decrease, especially in wellconditioned individuals. However, the overall impact of testosterone treatment combined with exercise on muscle mass gain and tissue loss remains inconclusive and necessitates further rigorous investigation through controlled clinical trials. Conclusion: the literature review suggests a need for further rigorous clinical trials to ascertain the efficacy and safety of such combined interventions, considering potential adverse events associated with testosterone treatment.

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:dbk:rehabi:v:4:y:2024:i::p:91:id:91

DOI: 10.56294/ri202491

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