Systematic review of neuroprotective actions of the ECP in the HT-22 neuronal line subjected to hypoxia and reoxygenation

Isabela Petrone Arifa and Lucas Daniel Udovin

Rehabilitation and Sports Medicine, 2026, vol. 6, 15

Abstract: Background: Palmitoylethanolamide (PEA) is an endogenous fatty acid amide that has recognized anti-inflammatory and analgesic actions. Given that inflammation, excitotoxicity, oxidation damage, and microvascular and blood-brain barrier dysfunction are neurodegenerative processes typical of cognitive impairment in diseases such as Alzheimer's and Parkinson's, it is considered possible that treatments with supplemental PEA can alleviate chronic pain and protect against neuronal damage. to the patient. The objective is to analyze neurodegenerative and anti-inflammatory protective actions of Palmitoylethanolamide (PEA) in murine hippocampal neuronal cell line HT-22 subjected to hypoxia and reoxygenation to apply in patients diagnosed with neurodegenerative diseases. Material and methods: The methodology applied was a systematic review of the literature, and the material used was 12 studies according to inclusion criteria. Results:Murine model and in patients focused on Alzheimer's and Parkinson's, being the effective treatment of PEA with antioxidant supplements, frequent protective action at the hippocampal level and modulation of cytokine and proteins in addition to a decrease in acetylcholine (ACh). Other neurodegenerative diseases may benefit from PEA with further specific investigations (in murine model or patients. Conclusion: Intracellular signaling under PEA and investigation into other neurodegenerative diseases should be further explored.

Date: 2026
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Persistent link: https://EconPapers.repec.org/RePEc:dbk:rehabi:v:6:y:2026:i::p:15:id:15

DOI: 10.56294/ri202615

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