Variable selection for multiply-imputed data with penalized generalized estimating equations

J. Geronimi and G. Saporta

Computational Statistics & Data Analysis, 2017, vol. 110, issue C, 103-114

Abstract: Generalized estimating equations (GEE) are useful tools for marginal regression analysis for longitudinal data. Having a high number of variables along with the presence of missing data presents complex issues when working in a longitudinal context. In variable selection for instance, penalized generalized estimating equations have not been systematically developed to integrate missing data. The MI-PGEE: multiple imputation-penalized generalized estimating equations, an extension of the multiple imputation-least absolute shrinkage and selection operator (MI-LASSO) is presented. MI-PGEE allows integration of missing data and within-subject correlation in variable selection procedures. Missing data are dealt with using multiple imputation, and variable selection is performed using a group LASSO penalty. Estimated coefficients for the same variable across multiply-imputed datasets are considered as a group while applying penalized generalized estimating equations, leading to a unique model across multiply-imputed datasets. In order to select the tuning parameter, a new BIC-like criterion is proposed. In a simulation study, the advantage of using MI-PGEE compared to simple imputation PGEE is shown. The usefulness of the new method is illustrated by an application to a subgroup of the placebo arm of the strontium ranelate efficacy in knee osteoarthritis trial study.

Keywords: Generalized estimating equations; LASSO; Longitudinal data; Missing data; Multiple imputation; Variable selection (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:eee:csdana:v:110:y:2017:i:c:p:103-114

DOI: 10.1016/j.csda.2017.01.001

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