Engineered Saccharomyces cerevisiae for sustainable biobased fuel production: Overcoming bottlenecks and implementing strategies

Ansuman Sahoo, Prabir Kumar Das, Venkata Dasu Veeranki and Sanjukta Patra

Renewable and Sustainable Energy Reviews, 2025, vol. 211, issue C

Abstract: The aim of net zero carbon emission and depleting petroleum reserves have pin-pointed the focus on renewable sources to meet the ever-increasing demand for fuel and high-value chemicals. Saccharomyces cerevisiae is an excellent host for commercial-scale production of biobased fuel due to its robustness in the industrial context, high productivity, and well-known genetic toolbox. However, incomplete sugar utilization and low product yield on renewable feedstocks are the hurdles to achieving consolidated bioprocessing, process efficiency and circular economy. Transporter engineering, transcriptional factor engineering, alteration of cofactor pool, increased resistance towards harsh conditions, and metabolic network rewiring strategies have been employed to eliminate the bottlenecks. Implementing strategies with the genome-scale metabolic model, flux balance analysis, and dynamic multi-omics approaches have fastened the developmental process to achieve a sustainable bioprocess. This review discusses recent advances in bioethanol, biobutanol, and precursors of biofuel production in S. cerevisiae from inexpensive, renewable lignocellulosic feedstock, emphasizing xylose utilization efficiency.

Keywords: Bioethanol; Butanol; Fatty alcohols; 2,3-BDO; Saccharomyces cerevisiae; Xylose; Genome-scale metabolic model (search for similar items in EconPapers)
Date: 2025
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DOI: 10.1016/j.rser.2025.115352

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