The ratio of morning cortisol to CRP prospectively predicts first-onset depression in at-risk adolescents

E.R. Landau, M.B. Raniti, M. Blake, J.M. Waloszek, L. Blake, J.G. Simmons, O. Schwartz, G. Murray, J. Trinder, N.B. Allen and M.L. Byrne

Social Science & Medicine, 2021, vol. 281, issue C

Abstract: Early-onset adolescent depression is related to poor prognosis and a range of psychiatric and medical comorbidities later in life, making the identification of a priori risk factors for depression highly important. Increasingly, dysregulated levels of immune and neuroendocrine markers, such as C-reactive protein (CRP) and cortisol, have been demonstrated as both precursors to and consequences of depression. However, longitudinal research with adolescent populations is limited and demonstrates mixed immuno-endocrine-depression links.

Keywords: Adolescence; Depression; C-reactive protein; Cortisol; Risk factors (search for similar items in EconPapers)
Date: 2021
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DOI: 10.1016/j.socscimed.2021.114098

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