“Are we not going too far?“: Socio-ethical considerations of preimplantation genetic testing using polygenic risk scores according to healthcare professionals

Maria Siermann, Ophelia Valcke, Joris Robert Vermeesch, Taneli Raivio, Olga Tšuiko and Pascal Borry

Social Science & Medicine, 2024, vol. 343, issue C

Abstract: The recent introduction of polygenic risk scores within preimplantation genetic testing (PGT-P) has been met with many concerns. To get more insights into the perspectives of relevant stakeholders on the socio-ethical aspects of PGT-P, an interview study with 31 healthcare professionals involved in reproductive medicine and genetics in Europe and North-America was performed. Healthcare professionals in our study were concerned that PGT-P was going too far in terms of selection, with regards to both medical conditions and non-medical traits. Healthcare professionals were worried about the ethical ‘slippery slope’ of PGT-P, the increasing medicalization of reproductive health, the commercial context of PGT-P, and potential stigmatization and discrimination. There were also concerns that the availability and the ‘technological imperative’ of PGT-P could lead to pressure and a sense of responsibility for parents to use PGT-P. Additionally, it could cause new anxieties about the child's health before the child has even been born. Since PGT-P provides polygenic risk scores before birth, the autonomy of the child has to be considered. These socio-ethical concerns heighten existing debates regarding reproductive genetic technologies and show that the specifics of PGT-P make this screening option especially ethically controversial.

Keywords: Attitudes; Ethics; Preimplantation genetic testing; Polygenic risk scores; Reproductive genetics; Qualitative methods; Europe; North-America (search for similar items in EconPapers)
Date: 2024
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DOI: 10.1016/j.socscimed.2024.116599

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