A Poisson model for gapped local alignments

Dirk Metzler, Steffen Grossmann and Anton Wakolbinger

Statistics & Probability Letters, 2002, vol. 60, issue 1, 91-100

Abstract: High score alignments of DNA sequences give evidence of a common ancestry or function. It is therefore natural to ask whether an observed high score could have arisen by pure chance, and to explore what the high score alignments look like under the null hypothesis of unrelated sequences. We introduce and investigate a simple Poisson model which reflects important features of high score gapped local alignments of independent sequences.

Keywords: Sequence; alignment; Gapped; local; alignment; Poisson; model; High; score; asymptotics (search for similar items in EconPapers)
Date: 2002
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