Synthesis and Antimicrobial Studies of 6-Aryl and 6-Anilino Benzo[a]phenoxazinones

Simon Sani Ocholi, Efeturi Abraham Onoabedje and Samuel Attah Egu
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Simon Sani Ocholi: University of Nigeria, Nigeria.
Efeturi Abraham Onoabedje: University of Nigeria, Nigeria.
Samuel Attah Egu: Kogi State University, Nigeria.

European Journal of Advanced Chemistry Research, 2020, vol. 1, issue 2

Abstract: Palladium catalyzed Suzuki-Miyaura (SM) and Buchwald – Hartwig (BH) cross-coupling reactions of some phenoxazines are reported. The precursor 9,11-diamino-6-chloro-7-oxa-8,10,12-triaza-benzo [a] anthracen-5-one was prepared by anhydrous base mediated reaction of 2,5,6-triamino-pyrimidin-4-ol and 2,3-dichloro-1,4-naphthoquinone in methanol. The molecular structures of the synthesized compounds agreed with UV/visible, FT-IR, 1H-NMR, MS and elemental analysis data. Using Ciprofloxacin and Ketoconazole as reference drugs, the compounds were screened against six (6) micro-organisms, viz: Listeria ivanovii, Staphylococcus aureus, Klebsiellapneumoniae, Escherichia coli, Candida albicans and Aspergillusnigerand were found to show significant activity against L.ivanovii and E. coli bacteria.

Keywords: Benzo[a]phenoxazinone; Buchwald–Hartwig; Cross-coupling; Palladium catalyzed; Phenoxazines; Phenothiazines; Suzuki-Miyaura. (search for similar items in EconPapers)
Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:epw:ejchem:v:1:y:2020:i:2:id:5004

DOI: 10.24018/ejchem.2020.1.2.4

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