The Motor Coordination Activity Of Aqueous Extract Of Withania Coagulans Fruits In Swiss Albino Mice By Rota Rod Test

Amit Shankarrao Kamdi, Devesh D. Gosavi, Suvarna M. Kalambe and Pankaj N. Bohra
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Amit Shankarrao Kamdi: Sanjeevani Multipurpose Society Mul, India
Devesh D. Gosavi: Mahatma Gandhi Institute of Medical Sciences, India
Suvarna M. Kalambe: Sanjeevani Multipurpose Society Mul, India
Pankaj N. Bohra: SNEH Foundation, India

European Journal of Medical and Health Sciences, 2020, vol. 2, issue 3

Abstract: Background: The various sedative and hypnotic medications used today have the central nervous system (CNS) depressant effects. A very little work has been done on the Withania coagulans – a vulnerable species as it is not found rampant in the world except in late seventies. Therefore, it was important to explore the CNS depressant activities of aqueous extract of Withania coagulans fruits in Swiss albino mice by using rota rod test. Methods: Motor coordination was assessed by using the Rota Rod Test. The CNS depressant drugs decrease the endurance time of mice on the rota rod as they impair the motor coordination so that mice fall early on the rotating rod. This endurance time is statistically correlated among the control, standard and the test drugs. Results: There was statistically highly significant (p-value

Keywords: CNS depressant; Swiss Albino Mice (SAM); Withania coagulans; rota rod test (search for similar items in EconPapers)
Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:epw:ejmed0:v:2:y:2020:i:3:id:40255

DOI: 10.24018/ejmed.2020.2.3.255

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