α-Glucosidase Inhibitory and Antiradical Properties of Acacia macrostachya

Hamidou Têeda Ganamé, Yssouf Karanga, Ousmane Ilboudo, Wende-Konté Hazael Conania Nikiema, Richard Wamtinga Sawadogo and Issa Tapsoba
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Hamidou Têeda Ganamé: Université Joseph KI-ZERBO, Burkina Faso
Yssouf Karanga: Université Joseph KI-ZERBO, Burkina Faso
Ousmane Ilboudo: Université Joseph KI-ZERBO, Burkina Faso
Wende-Konté Hazael Conania Nikiema: Institut de Recherche en Science de la Santé (IRSS/CNRST), Burkina Faso
Richard Wamtinga Sawadogo: Institut de Recherche en Science de la Santé (IRSS/CNRST), Burkina Faso
Issa Tapsoba: Université Joseph KI-ZERBO, Burkina Faso

European Journal of Medical and Health Sciences, 2020, vol. 2, issue 5

Abstract: In this work, the anti-diabetic activity of three extracts of Acacia macrostachya was investigated by following the inhibitory effect of these extracts on -glucosidase using the in vitro model. The antiradical activity of these extracts was also determined. Methanol extracts of root and stem barks showed a very significant inhibitory effect against the enzyme activity of -glucosidase with IC50 2.487 ± 0.441 µg/mL and 1.650 ± 0.229 µg/mL respectively. For antiradical activity, the same extracts presented the highest scavenging of the radical DPPH● with IC50 values of 9.307 ± 0.262 µg/mL and 5.242 ± 0.068 µg/mL respectively. With the cationic radical ABTS●+, IC50 varied from 45.049 ± 0.730 µg/mL for methanolic root barks extract to 14.136 ± 0.161 µg/mL for methanolic extract from stem barks. Thus, the methanol extracts of the root and stem barks of Acacia macrostachya possess compounds with very interesting anti-diabetic and antiradical properties and could justify its traditional use.

Keywords: Acacia macrostachya; Antiradical Activity; Diabetes; α-Glucosidase (search for similar items in EconPapers)
Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:epw:ejmed0:v:2:y:2020:i:5:id:40465

DOI: 10.24018/ejmed.2020.2.5.465

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