The Role of an Aqueous Extract of Cactus on Histopancreatic Architecture in Streptozotocin Induced Diabetes Mellitus in Wistar Rats

Uthman Ademola Yusuf, Francine Kafula, Kalande Kaimba, Wandi Kalipenta, Hellen Kabwe, John Amos Mulemena, Kingsley M. Kamvuma, Sam Beza Phiri, Michelo Miyoba, Bolaji Samuel Mesole, Adrian Phiri, Bwalya Bupe Bwalya and Wilson Zimba
Additional contact information
Uthman Ademola Yusuf: Mulungushi University, Zambia
Francine Kafula: Mulungushi University, Zambia
Kalande Kaimba: Mulungushi University, Zambia
Wandi Kalipenta: Mulungushi University, Zambia
Hellen Kabwe: Mulungushi University, Zambia
John Amos Mulemena: Mulungushi University, Zambia
Kingsley M. Kamvuma: Mulungushi University, Zambia
Sam Beza Phiri: Mulungushi University, Zambia
Michelo Miyoba: Mulungushi University, Zambia
Bolaji Samuel Mesole: Eden University, Zambia
Adrian Phiri: Mulungushi University, Zambia
Bwalya Bupe Bwalya: Mulungushi University, Zambia
Wilson Zimba: Mulungushi University, Zambia

European Journal of Pharmaceutical Research, 2022, vol. 2, issue 2, 11-16

Abstract: Herbs have been used as medicinal for several years to cure or rather manage different ailments such as diabetes mellitus. This is very common in rural settings of sub-saharan Africa and is now being adopted in urban areas. Opunta species have widely been seen to contain antihyperglycaemic effects. To evaluate the antihyperglycaemic and histopancreatic effect of aqueous extract of prickly pear cactus (Opuntia species) cladodes in streptozotocin-induced diabetic male Wistar rats in vivo. This was a laboratory based research conducted at Mulungushi University involving 30 wistar rats (Rattus norvegicus) that weighed between 160-200 g which were randomly selected into five groups (6 per cage); normal control, diabetic control, diabetic +metformin, diabetic +cactus and cactus only group. Initial blood glucose levels were obtained from the tail and record then Diabetes mellitus was induced using a single intraperitoneal dose of streptozotocin (70mg/kg BW) and established a persistent state of hyperglycemia after 72hours. The aqueous cactus extract of 100 mg/kg BW and metformin of 100 mg/kg BW was administered orally using intragastric cannula daily for a period of 4 weeks. At the end of the fourth week, Diabetes + cactus and diabetes + metformin groups body weights were statistically significant when compared to the diabetic group (P

Keywords: Cactus; diabetes mellitus; pancreas; streptozotocin; Wistar rat (search for similar items in EconPapers)
Date: 2022
References: Add references at CitEc
Citations:

Downloads: (external link)
https://eu-opensci.org/index.php/pharma/article/view/730 Abstract page (text/html)
https://eu-opensci.org/index.php/pharma/article/download/730/303 Full text (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:epw:pharma:v:2:y:2022:i:2:id:730

DOI: 10.24018/ejpharma.2022.2.2.30

Access Statistics for this article

More articles in European Journal of Pharmaceutical Research from European Open Science Publishing
Bibliographic data for series maintained by Support Team ().