Acute Antidepressant Activity Investigation of Selected African Medicinal Plants in Mice: A Preliminary Study

Ajibola Monisola Umarudeen, Mohammed Garba Magaji, Ferhat Khan and Abdulhakim Abubakar
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Ajibola Monisola Umarudeen: University of Abuja, Nigeria
Mohammed Garba Magaji: Ahmadu Bello University, Nigeria
Ferhat Khan: Ahmadu Bello University, Nigeria
Abdulhakim Abubakar: Ahmadu Bello University, Nigeria

European Journal of Pharmaceutical Research, 2023, vol. 3, issue 5, 1-6

Abstract: The therapeutic gap arising from high global incidence of depressive disorders and the efficacy and toxicity shortcomings of existing antidepressant drugs indicate a need to further search the plant kingdom with the goal of discovering novel antidepressant pharmacotherapeutic agents. Crude 50% ethanol Terminalia catappa (CETC), Tapinanthus dodoneifolius (CETD) and Bryophyllum pinnatum (CEBP) leaf extracts were investigated for their acute antidepressant activity on the forced swim (FST) and tail suspension (TST) tests. Groups of mice (n = 6) were each exposed to the tests 1 hour following oral administration of distilled water (10 ml/kg), extracts (125, 250 and 500 mg/kg body weight) and fluoxetine (20 mg/kg), using the mean immobility time as endpoint. Qualitative phytochemical analysis of these crude extracts indicated the presence of alkaloids, cardiac glycosides, saponins, phenolic compounds, tannins, steroids, carbohydrates, flavonoids, terpenoids and anthraquinones. Compared to distilled water treatments (FST, 84.16 ±3.92; TST, 82.85 ±5.84), CETC (FST, 84.17 ±4.44, 71.67 ±1.89, & 44.31 ±8.23*; TST, 79.03 ±2.62, 74.10 ±3.11, & 52.57 ±6.00*) and CEBP (FST, 77.02 ±2.70, 66.11 ±4.42 & 49.99 ±4.20*; TST, 69.51 ±7.24, 49.73 ±11.85* & 46.39 ±5.68**) treatments caused dose-dependent and significant (P

Keywords: Bryophyllum pinnatum; Crude ethanol; forced swim test; tail suspension test; Tapinanthus dodoneifolius; Terminalia catappa (search for similar items in EconPapers)
Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:epw:pharma:v:3:y:2023:i:5:id:766

DOI: 10.24018/ejpharma.2023.3.5.66

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