Formulation Development and Characterization of Self-Emulsifying Drug Delivery System (SEDDS) of Glibenclamide for Enhanced Solubility and Stability

Pranshu Saxena

International Journal of Scientific Research in Science and Technology, 2024, vol. 11, issue 6, 1119-1122

Abstract: Glibenclamide, a widely prescribed oral hypoglycemic agent, suffers from poor aqueous solubility and variable bioavailability, which limit its therapeutic efficacy. The present study aimed to develop and characterize a self-emulsifying drug delivery system (SEDDS) of Glibenclamide to improve its solubility and stability. Various oils, surfactants, and co-surfactants were screened for maximum solubility of Glibenclamide. Pseudo-ternary phase diagrams were constructed to identify the optimal region of self-emulsification. The optimized SEDDS formulation was characterized for droplet size, zeta potential, emulsification time, thermodynamic stability, drug content, and in-vitro dissolution. Results demonstrated that the optimized SEDDS achieved rapid emulsification (

Keywords: Glibenclamide; SEDDS; solubility enhancement; stability; drug delivery system (search for similar items in EconPapers)
Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:etm:ijsrst:v11:y2024:i6:id:1215

DOI: 10.32628/IJSRST25126247

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