Advanced Biologics and Smart Delivery Systems for Cardiovascular Diseases: A Comprehensive Review

Paras Ghasura, Bhavika Murlidhar Sajnani, Mohammad Azhar Tanveer, Barath Raj R and Abhishek Sharma

International Journal of Scientific Research in Science and Technology, 2025, vol. 12, issue 4, 217-221

Abstract: Background: Cardiovascular diseases (CVDs) remain the leading global cause of mortality, accounting for 20.5 million deaths annually. Traditional pharmacotherapies face limitations including poor bioavailability and systemic toxicity. Objective: To review the integration of advanced biological therapeutics with innovative drug delivery platforms for cardiovascular applications. Methods: Systematic analysis of 127 peer-reviewed articles from PubMed, Scopus, and Web of Science databases (2020-2025), focusing on FDA-approved biologics and emerging delivery technologies. Results: PCSK9 inhibitors demonstrate 50-60% LDL cholesterol reduction with significant cardiovascular event reduction. Advanced delivery systems including nanoparticles, stimuli-responsive carriers, and extracellular vesicles enhance therapeutic precision while minimizing adverse effects. Clinical successes include inclisiran achieving sustained efficacy with biannual dosing. Conclusion: The integration of biologics with smart delivery systems represents a paradigm shift toward personalized cardiovascular medicine with significant potential to improve patient outcomes.

Keywords: Cardiovascular diseases; biologics; nano medicine; drug delivery systems; PCSK9 inhibitors; targeted therapy (search for similar items in EconPapers)
Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:etm:ijsrst:v12:y2025:i4:id:1006

DOI: 10.32628/IJSRST251268

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