Complexation of Gadolinium Metal Ion with Medicinal Drugs in Mixed Solvent Media: Thermodynamic Aspect

Sandeep Sampal, Milind Gaikwad, Uddhav Chaudhar and Shailendrasingh Thakur

International Journal of Scientific Research in Science and Technology, 2025, vol. 12, issue 4, 1107-1113

Abstract: We have used a pH metric titration technique in a 20% (v/v) ethanol-water mixture at three different temperatures at an ionic strength of 0.1M NaClO4 to measure the proton-ligand and metal-ligand stability constants of medicinal drugs containing Gadolinium metal ion (Gd3+). The logK values of the metal-ligand stability constant have been determined using the modified Irving-Rossotti and Calvin-Bjerrum method. The thermodynamic parameters Gibb's free energy change, entropy change and enthalpy change related to the complexation reactions were quantitatively determined.

Keywords: pH metry; Gadolinium metal ion; medicinal drugs; Stability constants; Thermodynamic parameters (search for similar items in EconPapers)
Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:etm:ijsrst:v12:y2025:i4:id:1117

DOI: 10.32628/IJSRST251396

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