Design, Synthesis, and Characterization of Tetra-O-Acetyl-α-D-Glucosyl-Based 1,2,4-Dithiazolidines

Abhijit C. Shahu, Santosh B. Gaikwad and Kishore Puri

International Journal of Scientific Research in Science and Technology, 2026, vol. 13, issue 1, 470-475

Abstract: A series of new 4-phenyl-5-arylamino-3-S-tetra-O-acetyl-α-D-glucosyl-1,2,4-dithiazolidine derivatives were successfully synthesized through the reaction of Glucose-1-phenyl isothiocarbamate with a variety of N-aryl-S-chloro isothiocarbamoyl chlorides under controlled conditions. The synthetic route was effective and produced the desired compounds in good to moderate yields, showing that it can be used to make glucosyl dithiazolidine derivatives with different structures. Using different types of spectroscopy, such as mass spectrometry, infrared (IR) spectroscopy, and proton nuclear magnetic resonance (1H NMR) spectroscopy, the structures of the new N-glucosides were explained and confirmed. Characteristic spectral features, including absorption bands linked to functional groups and unique proton signals, corroborated the successful synthesis of the intended heterocyclic framework. These compounds are an important group of sulfur- and nitrogen-containing heterocycles that have a glucosyl group. They may have a lot of biological and pharmacological potential. The current study offers a simple way to make new glucosyl-based dithiazolidine derivatives and a reliable way to describe them for more research.

Keywords: Heterocyclic chemistry; N-glucosides; 1,2,4-dithiazolidine derivatives; Spectroscopic characterization; Glucosyl isothiocarbamates (search for similar items in EconPapers)
Date: 2026
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Persistent link: https://EconPapers.repec.org/RePEc:etm:ijsrst:v13:y2026:i1:id:1601

DOI: 10.32628/IJSRST26133138

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