Study of Antimicrobial Activity of Vegetable Alcoholic Extracts Obtained from Vinca Minor L

Ana-Maria Dumitrescu, Rodica Sirbu and Anca Cristina Lepä‚datu
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Ana-Maria Dumitrescu: IOSUD Carol Davila, Bucharest, Romania
Rodica Sirbu: "Ovidius" University of Constanta, Faculty of Pharmacy, Constanta, Romania
Anca Cristina Lepä‚datu: “Ovidius†University of Constanta, Faculty of Natural and Agricultural Sciences, Constanta, Romania

European Journal of Medicine and Natural Sciences, 2024, vol. 7, issue 1, 69-77

Abstract: Important natural antimicrobial compounds derived from Vinca minor L. plant contain a wide variety of secondary metabolites which are useful for brain health (increasing blood circulation in the brain, supporting brain metabolism, preventing memory loss and problems with concentration and premature aging of the cell), and externally they play a role in tissue repair and skin lesion healing. The testing of the antimicrobial activity of the alcoholic plant extracts obtained from Vinca minor plant was performed on two types of pathogenic germs: a Gram-positive strain, Staphylococcus aureus ATCC 25923 and a Gram-negative strain, Escherichia Coli ATCC 25922, as well as on a yeast strain pathogenic, Candida albicans ATCC 900288. Quantitative evaluation of antimicrobial activity was performed by a variant of the Kirby-Bauer diffusimetric method, a simple and fast method that allows the determination of the spectrum of sensitivity / resistance to antibiotics of the microorganism. Experimental studies have shown that all samples of alcoholic extract of 70 percent concentration, in volumes of 7µL, exerted a total antibacterial inhibitory action against the reference strains E. coli ATCC 25922 and C. albicans ATCC 10231 and moderate against the strain S. aureus ATCC 25923, results that agree with the literature. Regarding the alcoholic plant extracts with a concentration of 40 percent ethyl alcohol, obtained from the leaf and stem of Vinca minor plant, they did not show antimicrobial activity, which suggests that 40 percent ethyl alcohol does not extract bioactive compounds with antimicrobial activity.

Keywords: Vinca minor; bioactive substances; antimicrobial activity; Staphylococcus aureus; Escherichia Coli; C. albicans (search for similar items in EconPapers)
Date: 2024
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