Lomefloxacin—Occurrence in the German River Erft, Its Photo-Induced Elimination, and Assessment of Ecotoxicity

Melanie Voigt, Benjamin Hentschel, Nina Theiss, Christina Savelsberg, Indra Bartels, Anna Nickisch-Hartfiel and Martin Jaeger
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Melanie Voigt: Department of Chemistry and ILOC, Niederrhein University of Applied Sciences, D-47798 Krefeld, Germany
Benjamin Hentschel: Department of Chemistry and ILOC, Niederrhein University of Applied Sciences, D-47798 Krefeld, Germany
Nina Theiss: Department of Chemistry and ILOC, Niederrhein University of Applied Sciences, D-47798 Krefeld, Germany
Christina Savelsberg: Department of Chemistry and ILOC, Niederrhein University of Applied Sciences, D-47798 Krefeld, Germany
Indra Bartels: Department of Chemistry and ILOC, Niederrhein University of Applied Sciences, D-47798 Krefeld, Germany
Anna Nickisch-Hartfiel: Department of Chemistry and ILOC, Niederrhein University of Applied Sciences, D-47798 Krefeld, Germany
Martin Jaeger: Department of Chemistry and ILOC, Niederrhein University of Applied Sciences, D-47798 Krefeld, Germany

Clean Technol., 2020, vol. 2, issue 1, 1-17

Abstract: Pharmaceuticals in waters represent a worldwide problem of today. Advanced oxidation processes (AOPs) are being researched for elimination of the ecological hazard. Among the substances, the fluoroquinolone antibiotic lomefloxacin was selected for investigation in this study. Lomefloxacin (LOM) was found in the German river Erft. Near and far ultraviolet (UVA, UVC) radiation were used as AOPs and compared for efficiency depending on pH, water matrix, and catalysts. Chemical kinetics description revealed that UVC at pH 8–9 led to the fastest degradation of LOM. The catalysts hydrogen peroxide and titanium dioxide had only limited influence on the degradation rate. Seven novel transformation products were structurally identified by high-resolution higher-order mass spectrometry. Ecotoxicity of the novel and known compounds was assessed by quantitative structure-activity relationship (QSAR) analysis. In addition, irradiation time dependent minimal, and half-maximal inhibitory concentrations (MIC, IC 50 ) of LOM solutions were determined and suggested as ecotoxicological hazard indicators. From MIC and kinetic rate constants, the irradiation time required for compound and activity removal could be predicted.

Keywords: AOPs; assessment of ecotoxicity; fluoroquinolones; high resolution mass spectrometry; IC 50; MIC; QSAR (search for similar items in EconPapers)
JEL-codes: Q2 Q3 Q4 Q5 (search for similar items in EconPapers)
Date: 2020
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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