RNA Sequencing Dataset of Drosophila Nociceptor Translatomic Response to Injury

Christine M. Hale, Kyle J. Beauchemin, Courtney L. Brann, Julie K. Moulton, Ramaz Geguchadze, Benjamin J. Harrison and Geoffrey K. Ganter ()
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Christine M. Hale: College of Arts and Sciences, University of New England, 11 Hills Beach Road, Biddeford, ME 04103, USA
Kyle J. Beauchemin: College of Arts and Sciences, University of New England, 11 Hills Beach Road, Biddeford, ME 04103, USA
Courtney L. Brann: College of Arts and Sciences, University of New England, 11 Hills Beach Road, Biddeford, ME 04103, USA
Julie K. Moulton: College of Arts and Sciences, University of New England, 11 Hills Beach Road, Biddeford, ME 04103, USA
Ramaz Geguchadze: College of Osteopathic Medicine, University of New England, 11 Hills Beach Road, Biddeford, ME 04103, USA
Benjamin J. Harrison: College of Osteopathic Medicine, University of New England, 11 Hills Beach Road, Biddeford, ME 04103, USA
Geoffrey K. Ganter: College of Arts and Sciences, University of New England, 11 Hills Beach Road, Biddeford, ME 04103, USA

Data, 2025, vol. 10, issue 2, 1-7

Abstract: To prepare to address the mechanisms of injury-induced nociceptor sensitization, we sequenced the translatome of the nociceptors of injured Drosophila larvae and those of uninjured larvae. Third-instar larvae expressing a green fluorescent protein (GFP)-tagged ribosomal subunit specifically in Class 4 dendritic arborization neurons, recognized as pickpocket-expressing primary nociceptors, via the GAL4/UAS method, were injured by ultraviolet light or sham-injured. Larvae were subjected to translating ribosome affinity purification for the GFP tag and nociceptor-specific ribosome-bound RNA was sequenced.

Keywords: allodynia; hyperalgesia; RNAseq; nociceptor; pain; sensitization (search for similar items in EconPapers)
JEL-codes: C8 C80 C81 C82 C83 (search for similar items in EconPapers)
Date: 2025
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