Time-Course Transcriptomic Dataset of Gallic Acid-Induced Human Cervical Carcinoma HeLa Cell Death

Ho Man Tang and Peter Chi Keung Cheung ()
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Ho Man Tang: School of Life Sciences, Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Peter Chi Keung Cheung: School of Life Sciences, Chinese University of Hong Kong, Shatin, Hong Kong SAR, China

Data, 2025, vol. 10, issue 5, 1-12

Abstract: Gallic acid is a natural phenolic acid that displays potent anti-cancer activity in a large variety of cell types and rodent cancer xenograft models. Although research has focused on determining the efficacy of gallic acid against various types of human cancer cells, the molecular mechanisms governing the anti-cancer properties of gallic acid remain largely unclear, and a transcriptomic study of gallic acid-induced cancer cell death has rarely been reported. Therefore, we applied time-course bulk RNA-sequencing to elucidate the molecular signature of gallic acid-induced cell death in human cervical cancer HeLa cells, as this is a widely used in vitro model in the field. Our RNA-sequencing dataset covers the early (2 nd hour), middle (4 th , 6 th hour), and late (9 th hour) stages of the cell death process after exposure of HeLa cells to gallic acid, and the untreated (0 th hour) cells served as controls. Differential expression of messenger RNAs (mRNAs) and long non-coding RNAs (lncRNAs) was identified at each time point in the dataset. In summary, this dataset is a unique and valuable resource with which the scientific community can explore the molecular mechanisms and identify druggable regulators of the gallic acid-induced cell death process in cancer.

Keywords: gallic acid; HeLa cells; RNA-seq; cell death; apoptosis; ferroptosis; necroptosis; mRNA; lncRNA; gene expression (search for similar items in EconPapers)
JEL-codes: C8 C80 C81 C82 C83 (search for similar items in EconPapers)
Date: 2025
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