Microstructural and Metabolic Recovery of Anhedonic Rat Brains: An In Vivo Diffusion MRI and 1 H-MRS Approach

Ahmad Raza Khan, Sune Nørhøj Jespersen, Ove Wiborg, Christopher Kroenke and Brian Hansen
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Ahmad Raza Khan: Center of Functionally Integrative Neuroscience, Aarhus University Hospital, 8000 Aarhus, Denmark
Sune Nørhøj Jespersen: Center of Functionally Integrative Neuroscience, Aarhus University Hospital, 8000 Aarhus, Denmark
Ove Wiborg: Center of Functionally Integrative Neuroscience, Aarhus University Hospital, 8000 Aarhus, Denmark
Christopher Kroenke: Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR 97239, USA
Brian Hansen: Center of Functionally Integrative Neuroscience, Aarhus University Hospital, 8000 Aarhus, Denmark

Data, 2018, vol. 3, issue 3, 1-4

Abstract: This article presents longitudinal 1 H-MR Spectroscopy ( 1 H-MRS) data from ventral hippocampus and in vivo diffusion MRI (dMRI) data of the brain from control and anhedonic rats. The 1 H-MRS and dMRI data were acquired using a 9.4 T preclinical imaging system. Before MRI experiments, animals were exposed to unpredictable chronic mild stress exposure for eight weeks and on the basis of a sucrose consumption test were identified as anhedonic and resilient. An age-matched group of animals, unexposed to the unpredictable chronic mild stress paradigm was considered as control. Data was acquired at the age of 18, 20 and 25 weeks in the anhedonic group and at the age of 18 and 22 weeks in the control group. This multimodal MRI data provides metabolic information of ventral hippocampus and dMRI based microstructural parameters of the brain.

Keywords: diffusion MRI; 1 H-MRS; chronic mild stress; kurtosis; hippocampus; amygdala (search for similar items in EconPapers)
JEL-codes: C8 C80 C81 C82 C83 (search for similar items in EconPapers)
Date: 2018
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