Information System for Selection of Conditions and Equipment for Mammalian Cell Cultivation

Natalia Menshutina, Elena Guseva, Diana Batyrgazieva and Igor Mitrofanov
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Natalia Menshutina: Department of Cybernetics of Chemical Technological Processes, Mendeleev University of Chemical Technology of Russia, Miusskaya Sq., 9, 125047 Moscow, Russia
Elena Guseva: Department of Cybernetics of Chemical Technological Processes, Mendeleev University of Chemical Technology of Russia, Miusskaya Sq., 9, 125047 Moscow, Russia
Diana Batyrgazieva: Department of Cybernetics of Chemical Technological Processes, Mendeleev University of Chemical Technology of Russia, Miusskaya Sq., 9, 125047 Moscow, Russia
Igor Mitrofanov: Department of Cybernetics of Chemical Technological Processes, Mendeleev University of Chemical Technology of Russia, Miusskaya Sq., 9, 125047 Moscow, Russia

Data, 2021, vol. 6, issue 3, 1-17

Abstract: Over the past few decades, animal cell culture technology has advanced significantly. It is now considered a reliable, functional, and relatively well-developed technology. At present, biotherapeutic drugs are synthesized using cell culture techniques by large manufacturing enterprises that produce products for commercial use and clinical research. The reliable implementation of mammalian cell culture technology requires the optimization of a number of variables, including the culture environment and bioreactor conditions, suitable cell lines, operating costs, efficient process management and, most importantly, quality. Successful implementation also requires an appropriate process development strategy, industrial scale, and characteristics, as well as the certification of sustainable procedures that meet the requirements of current regulations. All of this has led to a trend of increasing research in the field of biotechnology and, as a result, to a great accumulation of scientific information which, however, remains fragmentary and non-systematic. The development of information and network technologies allow us to solve this problem. Information system creation allows for implementation of the modern concept of integrating various structured and unstructured data, as well as the collection of information from internal and external sources. We propose and develop an information system which contains the conditions and various parameters of cultivation processes. The associated ranking system is the result of the set of recommendations—both from technological and hardware solutions—which allow for choosing the optimal conditions for the cultivation of mammalian cells at the stage of scientific research, thereby significantly reducing the time and cost of work. The proposed information system allows for the accumulation of experience regarding existing technologies for the cultivation of mammalian cells, along with application to the development of new technologies. The main goal of the present work is to discuss information systems, the organizational support of scientific research in the field of mammalian cell cultivation, and to provide a detailed description of the developed system and its main modules, including the conceptual and logical scheme of the database.

Keywords: cultivation of mammalian cells; information system; biotechnology; digital technologies; regenerative medicine (search for similar items in EconPapers)
JEL-codes: C8 C80 C81 C82 C83 (search for similar items in EconPapers)
Date: 2021
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