Comprehensive Landscape of STEAP Family Members Expression in Human Cancers: Unraveling the Potential Usefulness in Clinical Practice Using Integrated Bioinformatics Analysis

Sandra M. Rocha, Sílvia Socorro, Luís A. Passarinha and Cláudio J. Maia
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Sandra M. Rocha: CICS-UBI—Health Sciences Research Center, Universidade da Beira Interior, 6201-506 Covilhã, Portugal
Sílvia Socorro: CICS-UBI—Health Sciences Research Center, Universidade da Beira Interior, 6201-506 Covilhã, Portugal
Luís A. Passarinha: CICS-UBI—Health Sciences Research Center, Universidade da Beira Interior, 6201-506 Covilhã, Portugal
Cláudio J. Maia: CICS-UBI—Health Sciences Research Center, Universidade da Beira Interior, 6201-506 Covilhã, Portugal

Data, 2022, vol. 7, issue 5, 1-48

Abstract: The human Six-Transmembrane Epithelial Antigen of the Prostate (STEAP) family comprises STEAP1-4. Several studies have pointed out STEAP proteins as putative biomarkers, as well as therapeutic targets in several types of human cancers, particularly in prostate cancer. However, the relationships and significance of the expression pattern of STEAP1-4 in cancer cases are barely known. Herein, the Oncomine database and cBioPortal platform were selected to predict the differential expression levels of STEAP members and clinical prognosis. The most common expression pattern observed was the combination of the over- and underexpression of distinct STEAP genes, but cervical and gastric cancer and lymphoma showed overexpression of all STEAP genes. It was also found that STEAP genes’ expression levels were already deregulated in benign lesions. Regarding the prognostic value, it was found that STEAP1 (prostate), STEAP2 (brain and central nervous system), STEAP3 (kidney, leukemia and testicular) and STEAP4 (bladder, cervical, gastric) overexpression correlate with lower patient survival rate. However, in prostate cancer, overexpression of the STEAP4 gene was correlated with a higher survival rate. Overall, this study first showed that the expression levels of STEAP genes are highly variable in human cancers, which may be related to different patients’ outcomes.

Keywords: STEAP members; human cancers; Oncomine; prognosis; cBioPortal (search for similar items in EconPapers)
JEL-codes: C8 C80 C81 C82 C83 (search for similar items in EconPapers)
Date: 2022
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