Low-Dose Radiation-Induced Transcriptomic Changes in Diabetic Aortic Endothelial Cells

Jihye Park, Kyuho Kang, Yeonghoon Son, Kwang Seok Kim, Keunsoo Kang () and Hae-June Lee ()
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Jihye Park: Department of Microbiology, College of Science & Technology, Dankook University, Cheonan 31116, Republic of Korea
Kyuho Kang: Department of Biological Sciences and Biotechnology, Chungbuk National University, Cheongju 28644, Republic of Korea
Yeonghoon Son: Divisions of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea
Kwang Seok Kim: Divisions of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea
Keunsoo Kang: Department of Microbiology, College of Science & Technology, Dankook University, Cheonan 31116, Republic of Korea
Hae-June Lee: Divisions of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea

Data, 2023, vol. 8, issue 5, 1-7

Abstract: Low-dose radiation refers to exposure to ionizing radiation at levels that are generally considered safe and not expected to cause immediate health effects. However, the effects of low-dose radiation are still not fully understood, and research in this area is ongoing. In this study, we investigated the alterations in gene expression profiles of human aortic endothelial cells (HAECs) and diabetic human aortic endothelial cells (T2D-HAECs) derived from patients with type 2 diabetes. To this end, we used RNA-seq to profile the transcriptomes of cells exposed to varying doses of low-dose radiation (0.1 Gy, 0.5 Gy, and 2.0 Gy) and compared them to a control group with no radiation exposure. Differentially expressed genes and enriched pathways were identified using the DESeq2 and gene set enrichment analysis (GSEA) methods, respectively. The data generated in this study are publicly available through the gene expression omnibus (GEO) database with the accession number GSE228572. This study provides a valuable resource for examining the effects of low-dose radiation on HAECs and T2D-HAECs, thereby contributing to a better understanding of the potential human health risks associated with low-dose radiation exposure.

Keywords: low-dose radiation; RNA-seq; type 2 diabetes; transcriptomes; diabetic human aortic endothelial cells; human aortic endothelial cells; HAEC; T2D-HAEC (search for similar items in EconPapers)
JEL-codes: C8 C80 C81 C82 C83 (search for similar items in EconPapers)
Date: 2023
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