OSBA: An Open Neonatal Neuroimaging Atlas and Template for Spina Bifida Aperta

Anna Speckert, Hui Ji, Kelly Payette, Patrice Grehten, Raimund Kottke, Samuel Ackermann, Beth Padden, Luca Mazzone, Ueli Moehrlen, Spina Bifida Study Group Zurich and Andras Jakab ()
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Anna Speckert: Center for MR-Research, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
Hui Ji: Center for MR-Research, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
Kelly Payette: Center for MR-Research, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
Patrice Grehten: Department of Diagnostic Imaging, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
Raimund Kottke: Department of Diagnostic Imaging, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
Samuel Ackermann: Center for MR-Research, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
Beth Padden: Division of Pediatric Rehabilitation, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
Luca Mazzone: Zurich Center for Spina Bifida, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
Ueli Moehrlen: Zurich Center for Spina Bifida, University Children’s Hospital Zurich, 8032 Zurich, Switzerland
Spina Bifida Study Group Zurich: Spina Bifida Study Group Zurich, Zurich, Switzerland
Andras Jakab: Center for MR-Research, University Children’s Hospital Zurich, 8032 Zurich, Switzerland

Data, 2024, vol. 9, issue 9, 1-13

Abstract: We present the Open Spina Bifida Aperta (OSBA) atlas, an open atlas and set of neuroimaging templates for spina bifida aperta (SBA). Traditional brain atlases may not adequately capture anatomical variations present in pediatric or disease-specific cohorts. The OSBA atlas fills this gap by representing the computationally averaged anatomy of the neonatal brain with SBA after fetal surgical repair. The OSBA atlas was constructed using structural T2-weighted and diffusion tensor MRIs of 28 newborns with SBA who underwent prenatal surgical correction. The corrected gestational age at MRI was 38.1 ± 1.1 weeks (mean ± SD). The OSBA atlas consists of T2-weighted and fractional anisotropy templates, along with nine tissue prior maps and region of interest (ROI) delineations. The OSBA atlas offers a standardized reference space for spatial normalization and anatomical ROI definition. Our image segmentation and cortical ribbon definition are based on a human-in-the-loop approach, which includes manual segmentation. The precise alignment of the ROIs was achieved by a combination of manual image alignment and automated, non-linear image registration. From the clinical and neuroimaging perspective, the OSBA atlas enables more accurate spatial standardization and ROI-based analyses and supports advanced analyses such as diffusion tractography and connectomic studies in newborns affected by this condition.

Keywords: spina bifida aperta; neonatal atlas; T2-weighted MRI; diffusion MRI (search for similar items in EconPapers)
JEL-codes: C8 C80 C81 C82 C83 (search for similar items in EconPapers)
Date: 2024
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