OptoBrain: A Wireless Sensory Interface for Optogenetics

Rodrigo de Albuquerque Pacheco Andrade, Helder Eiki Oshiro, Gabriel Augusto Ginja, Eduardo Colombari, Maria Celeste Dias, José A. Afonso () and João Paulo Pereira do Carmo
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Rodrigo de Albuquerque Pacheco Andrade: Department of Electrical Engineering and Computer Science, University of Sao Paulo, Av. Trab. São Carlense, 400—Parque Arnold Schimidt, São Carlos 13566-590, SP, Brazil
Helder Eiki Oshiro: Department of Electrical Engineering and Computer Science, University of Sao Paulo, Av. Trab. São Carlense, 400—Parque Arnold Schimidt, São Carlos 13566-590, SP, Brazil
Gabriel Augusto Ginja: Department of Electrical Engineering and Computer Science, University of Sao Paulo, Av. Trab. São Carlense, 400—Parque Arnold Schimidt, São Carlos 13566-590, SP, Brazil
Eduardo Colombari: Department of Physiology and Pathology, State University of São Paulo (UNESP), Rua Humaitá, 1680 Centro, Araraquara 14801-903, SP, Brazil
Maria Celeste Dias: Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal
José A. Afonso: Center for Microelectromechanical Systems (CMEMS), University of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal
João Paulo Pereira do Carmo: Department of Electrical Engineering and Computer Science, University of Sao Paulo, Av. Trab. São Carlense, 400—Parque Arnold Schimidt, São Carlos 13566-590, SP, Brazil

Future Internet, 2025, vol. 17, issue 10, 1-28

Abstract: Optogenetics leverages light to control neural circuits, but traditional systems are often bulky and tethered, limiting their use. This work introduces OptoBrain, a novel, portable wireless system for optogenetics designed to overcome these challenges. The system integrates modules for multichannel data acquisition, smart neurostimulation, and continuous processing, with a focus on low-power and low-voltage operation. OptoBrain features up to eight neuronal acquisition channels with a low input-referred noise (e.g., 0.99 µVRMS at 250 sps with 1 V/V gain), and reliably streams data via a Bluetooth 5.0 link at a measured throughput of up to 400 kbps. Experimental results demonstrate robust performance, highlighting its potential as a simple, practical, and low-cost solution for emerging optogenetics research centers and enabling new avenues in neuroscience.

Keywords: optogenetics; microdevice; biopotencial acquisition; neurostimulation (search for similar items in EconPapers)
JEL-codes: O3 (search for similar items in EconPapers)
Date: 2025
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