Maternal Exposure to Bisphenol-A and Fetal Growth Restriction: A Case-Referent Study

Igor Burstyn, Jonathan W. Martin, Sanjay Beesoon, Fiona Bamforth, Qiaozhi Li, Yutaka Yasui and Nicola M. Cherry
Additional contact information
Igor Burstyn: Division of Preventive Medicine, Department of Medicine, Faculty of Medicine and Dentistry, The University of Alberta, Edmonton, AB T6G 2G3, Canada
Jonathan W. Martin: Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, The University of Alberta, Edmonton, AB T6G 2B7, Canada
Sanjay Beesoon: Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, The University of Alberta, Edmonton, AB T6G 2B7, Canada
Fiona Bamforth: Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, The University of Alberta, Edmonton, AB T6G 2B7, Canada
Qiaozhi Li: School of Public Health, The University of Alberta, Edmonton, AB T6G 1C9, Canada
Yutaka Yasui: School of Public Health, The University of Alberta, Edmonton, AB T6G 1C9, Canada
Nicola M. Cherry: Division of Preventive Medicine, Department of Medicine, Faculty of Medicine and Dentistry, The University of Alberta, Edmonton, AB T6G 2G3, Canada

IJERPH, 2013, vol. 10, issue 12, 1-14

Abstract: We conducted a case-referent study of the effect of exposure to bisphenol-A on fetal growth in utero in full-term, live-born singletons in Alberta, Canada. Newborns <10 percentile of expected weight for gestational age and sex were individually matched on sex, maternal smoking and maternal age to referents with weight appropriate to gestational age. Exposure of the fetus to bisphenol-A was estimated from maternal serum collected at 15–16 weeks of gestation. We pooled sera across subjects for exposure assessment, stratified on case-referent status and sex. Individual 1:1 matching was maintained in assembling 69 case and 69 referent pools created from 550 case-referent pairs. Matched pools had an equal number of aliquots from individual women. We used an analytical strategy conditioning on matched set and total pool-level values of covariates to estimate individual-level effects. Pools of cases and referents had identical geometric mean bisphenol-A concentrations (0.5 ng/mL) and similar geometric standard deviations (2.3–2.5). Mean difference in concentration between matched pools was 0 ng/mL, standard deviation: 1 ng/mL. Stratification by sex and control for confounding did not suggest bisphenol-A increased fetal growth restriction. Our analysis does not provide evidence to support the hypothesis that bisphenol-A contributes to fetal growth restriction in full-term singletons.

Keywords: BPA; endocrine disruption; small for gestation age; birth weight; epidemiology (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2013
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.mdpi.com/1660-4601/10/12/7001/pdf (application/pdf)
https://www.mdpi.com/1660-4601/10/12/7001/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:10:y:2013:i:12:p:7001-7014:d:31235

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().