Assessing Organ Doses from Paediatric CT Scans—A Novel Approach for an Epidemiology Study (the EPI-CT Study)

Isabelle Thierry-Chef, Jérémie Dabin, Eva G. Friberg, Johannes Hermen, Tore S. Istad, Andreas Jahnen, Lucian Krille, Choonsik Lee, Carlo Maccia, Arvid Nordenskjöld, Hilde M. Olerud, Kaddour Rani, Jean-Luc Rehel, Steven L. Simon, Lara Struelens and Ausrele Kesminiene
Additional contact information
Isabelle Thierry-Chef: International Agency for Research on Cancer, 150, Cours Albert Thomas, Lyon 69008, France
Jérémie Dabin: Belgian Nuclear Research Centre, SCK·CEN, Boeretang 200, Mol 2400, Belgium
Eva G. Friberg: Norwegian Radiation Protection Authority, P.O. Box 55, Østerås 1332, Norway
Johannes Hermen: Public Research Center Henri Tudor, 29, Avenue John F. Kennedy, 1855, Luxembourg
Tore S. Istad: Norwegian Radiation Protection Authority, P.O. Box 55, Østerås 1332, Norway
Andreas Jahnen: Public Research Center Henri Tudor, 29, Avenue John F. Kennedy, 1855, Luxembourg
Lucian Krille: Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Obere-Zahlbacher-Str 69, Mainz 55131, Germany
Choonsik Lee: Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute, NIH, DHHS 6120 Executive Blvd. EPS Rockville, MD 20852, USA
Carlo Maccia: CAATS 43, Bd Maréchal Joffre, Bourg-La-Reine 92340, France
Arvid Nordenskjöld: Clinical Epidemiology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, M9:01 SE-171, Stockholm 76, Sweden
Hilde M. Olerud: Norwegian Radiation Protection Authority, P.O. Box 55, Østerås 1332, Norway
Kaddour Rani: Public Research Center Henri Tudor, 29, Avenue John F. Kennedy, 1855, Luxembourg
Jean-Luc Rehel: Radiation Protection and Nuclear Safety Institute, PRP-HOM/SER/UEM, BP 17, Fontenay-aux-Roses 92 262, France
Steven L. Simon: Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute, NIH, DHHS 6120 Executive Blvd. EPS Rockville, MD 20852, USA
Lara Struelens: Belgian Nuclear Research Centre, SCK·CEN, Boeretang 200, Mol 2400, Belgium
Ausrele Kesminiene: International Agency for Research on Cancer, 150, Cours Albert Thomas, Lyon 69008, France

IJERPH, 2013, vol. 10, issue 2, 1-12

Abstract: The increasing worldwide use of paediatric computed tomography (CT) has led to increasing concerns regarding the subsequent effects of exposure to radiation. In response to this concern, the international EPI-CT project was developed to study the risk of cancer in a large multi-country cohort. In radiation epidemiology, accurate estimates of organ-specific doses are essential. In EPI-CT, data collection is split into two time periods—before and after introduction of the Picture Archiving Communication System (PACS) introduced in the 1990s. Prior to PACS, only sparse information about scanner settings is available from radiology departments. Hence, a multi-level approach was developed to retrieve information from a questionnaire, surveys, scientific publications, and expert interviews. For the years after PACS was introduced, scanner settings will be extracted from Digital Imaging and Communications in Medicine (DICOM) headers, a protocol for storing medical imaging data. Radiation fields and X-ray interactions within the body will be simulated using phantoms of various ages and Monte-Carlo-based radiation transport calculations. Individual organ doses will be estimated for each child using an accepted calculation strategy, scanner settings, and the radiation transport calculations. Comprehensive analyses of missing and uncertain dosimetry data will be conducted to provide uncertainty distributions of doses.

Keywords: paediatric computed tomography; organ dose reconstruction; scanner settings; leukaemia; cancer risk (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2013
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