Levels of Pesticides and Their Metabolites in Wistar Rat Amniotic Fluids and Maternal Urine upon Gestational Exposure

Rossana Bossi, Anne Marie Vinggaard, Camilla Taxvig, Julie Boberg and Eva Cecilie Bonefeld-Jørgensen
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Rossana Bossi: Department of Environmental Science, Aarhus University, Frederiksborgvej 399, Roskilde 4000, Denmark
Anne Marie Vinggaard: National Food Institute, Technical University of Denmark, Department of Toxicology and Risk Assessment, Mørkhøj Bygade 19, Søborg 2860, Denmark
Camilla Taxvig: National Food Institute, Technical University of Denmark, Department of Toxicology and Risk Assessment, Mørkhøj Bygade 19, Søborg 2860, Denmark
Julie Boberg: National Food Institute, Technical University of Denmark, Department of Toxicology and Risk Assessment, Mørkhøj Bygade 19, Søborg 2860, Denmark
Eva Cecilie Bonefeld-Jørgensen: Centre for Arctic Health and Unit for Cellular & Molecular Toxicology, Department of Public Health, Build. 1260, Bartholins Allé 2, Aarhus University, Aarhus C 8000, Denmark

IJERPH, 2013, vol. 10, issue 6, 1-11

Abstract: Concentrations of pesticides and selected metabolites in rat urine and amniotic fluid were determined as biomarker upon oral administration of Wistar rats to two pesticide mixtures consisting of three to five pesticides (bitertanol, propiconazole, cypermethrin, malathion, and terbuthylazine). The pesticides and their metabolites were found in rat amniotic fluid and urine, generally in dose-response concentrations in relation to dosage. The measurement of the substances in the amniotic fluid indicated that the fetus was exposed to the pesticides as well as their metabolites. Moreover, the pesticides detected in urine demonstrated the exposure as well as the ability of the rat to excrete these compounds.

Keywords: pesticides; gestational exposure; in vivo experiment; Wistar rats (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2013
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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