Protective Effects of Sodium Selenite against Aflatoxin B 1 -Induced Oxidative Stress and Apoptosis in Broiler Spleen

Fengyuan Wang, Gang Shu, Xi Peng, Jing Fang, Kejie Chen, Hengmin Cui, Zhengli Chen, Zhicai Zuo, Junliang Deng, Yi Geng and Weimin Lai
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Fengyuan Wang: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
Gang Shu: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
Xi Peng: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
Jing Fang: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
Kejie Chen: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
Hengmin Cui: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
Zhengli Chen: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
Zhicai Zuo: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
Junliang Deng: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
Yi Geng: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
Weimin Lai: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China

IJERPH, 2013, vol. 10, issue 7, 1-11

Abstract: The aim of this study was to investigate the possible protective role of sodium selenite on aflatoxin B 1 -induced oxidative stress and apoptosis in spleen of broilers. Two hundred one-day-old male broilers, divided into five groups, were fed with basal diet (control group), 0.3 mg/kg AFB 1 (AFB 1 group), 0.3 mg/kg AFB 1 + 0.2 mg/kg Se (+Se group I), 0.3 mg/kg AFB 1 + 0.4 mg/kg Se (+Se group II) and 0.3 mg/kg AFB 1 + 0.6 mg/kg Se (+Se group III), respectively. According to biochemical assays, AFB 1 significantly decreased the activities of glutathione peroxidase, total superoxide dismutase, glutathione reductase, catalase and the level of glutathione hormone, while it increased the level of malondialdehyde. Moreover, AFB 1 increased the percentage of apoptosis cells by flow cytometry and the occurrence of apoptotic cells by TUNEL assay. Simultaneous supplementation with sodium selenite restored these parameters to be close to those in control group. In conclusion, sodium selenite exhibited protective effects on AFB 1 -induced splenic toxicity in broilers by inhibiting oxidative stress and excessive apoptosis.

Keywords: aflatoxin b 1; sodium selenite; oxidative stress; apoptosis; spleen (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2013
References: View complete reference list from CitEc
Citations: View citations in EconPapers (6)

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