Association between Metabolic Syndrome and Chronic Kidney Disease in Perimenopausal Women

Yongqiang Li, Liqin Zhao, Youming Chen, Aiqun Liu, Xinyu Liu, Xiaofei Shao, Ying Zhang, Honglei Wang, Xiaohong Wang, Bin Li, Kangping Deng, Qin Liu, Harry Holthöfer and Hequn Zou
Additional contact information
Yongqiang Li: Department of Nephronology, Institute of Nephronology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China
Liqin Zhao: The Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China
Youming Chen: Clinical laboratory, the Third Affiliated Hospital of Southern, Medical University, Guangzhou 510630, China
Aiqun Liu: Department of Nephronology, Institute of Nephronology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China
Xinyu Liu: Department of Nephronology, Institute of Nephronology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China
Xiaofei Shao: Department of Nephronology, Institute of Nephronology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China
Ying Zhang: Department of Nephronology, Institute of Nephronology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China
Honglei Wang: Department of Nephronology, Institute of Nephronology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China
Xiaohong Wang: Department of Nephronology, Institute of Nephronology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China
Bin Li: Department of Nephronology, Institute of Nephronology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China
Kangping Deng: Department of Nephronology, Institute of Nephronology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China
Qin Liu: Department of Nephronology, Institute of Nephronology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China
Harry Holthöfer: National Centre for Sensor Research/BioAnalytical Sciences, Dublin City University, Dublin 9, Ireland
Hequn Zou: Department of Nephronology, Institute of Nephronology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China

IJERPH, 2013, vol. 10, issue 9, 1-11

Abstract: The purpose of the study was to explore the association between metabolic syndrome (MetS) and chronic kidney disease (CKD) in perimenopausal women. A cross-sectional study was conducted in Zhuhai from June to October 2012. Perimenopausal women (n = 685) were included in the study. All participants were divided into three subgroups: Group 1, 40 years old ? Age < 50 years old; Group 2, 50 years old ? Age < 60 years old; Group 3, 60 years old ? Age ? 65 years old. MetS was associated with CKD ( p < 0.01) in the unadjusted analyses in total subjects. After adjusting the potential confounders, the odd ratios of CKD for MetS was 2.66 (95% CI 1.56 to 4.49, p < 0.001). There was no relationship between MetS and CKD in both Group 1 and Group 3. MetS was associated with CKD ( p < 0.001) in the unadjusted analyses in Group 2. After adjusting for potential confounders, MetS was significantly associated with CKD. The odd ratios for MetS was 6.79 (95% CI 2.30 to 20.09, p < 0.001). There was no relationship between elevated blood pressure, elevated fasting glucose, abdominal obesity, Low HDL cholesterol, elevated triglycerides and CKD in both Group 1 and Group 3. Elevated blood pressure was associated with CKD in Group 2 (unadjusted Odds ratio: 4.52 (1.28–16.02), p = 0.02). After adjusting for potential confounders, there was no relationship between elevated blood pressure and CKD ( p = 0.78). Elevated fasting glucose was associated with CKD in Group 2 (unadjusted Odds ratio: 3.69 (1.10–12.38), p = 0.03). After adjusting for potential confounders, there was no relationship between elevated fasting glucose and CKD ( p = 0.15). There was no relationship between abdominal obesity, Low HDL cholesterol, elevated triglycerides and CKD in Group 2. These findings suggest that in perimenopausal women aged from 50 or older to 60 MetS was associated with CKD. There is no relationship between MetS and CKD in perimenopausal women aged from 40 or older to 50 and aged from 60 or older to 65.

Keywords: metabolic syndrome; chronic kidney disease; perimenopausal women (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2013
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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