The Study of External Dose Rate and Retained Body Activity of Patients Receiving 131 I Therapy for Differentiated Thyroid Carcinoma

Haiying Zhang, Ling Jiao, Songye Cui, Liang Wang, Jian Tan, Guizhi Zhang, Yajing He, Shuzhou Ruan, Saijun Fan and Wenyi Zhang
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Haiying Zhang: Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute Of Radiation Medicine, Chinese Academy Of Medical Sciences & Peking Union Medical College, Tianjin 300192, China
Ling Jiao: Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute Of Radiation Medicine, Chinese Academy Of Medical Sciences & Peking Union Medical College, Tianjin 300192, China
Songye Cui: Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute Of Radiation Medicine, Chinese Academy Of Medical Sciences & Peking Union Medical College, Tianjin 300192, China
Liang Wang: Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute Of Radiation Medicine, Chinese Academy Of Medical Sciences & Peking Union Medical College, Tianjin 300192, China
Jian Tan: Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China
Guizhi Zhang: Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China
Yajing He: Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China
Shuzhou Ruan: Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute Of Radiation Medicine, Chinese Academy Of Medical Sciences & Peking Union Medical College, Tianjin 300192, China
Saijun Fan: Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute Of Radiation Medicine, Chinese Academy Of Medical Sciences & Peking Union Medical College, Tianjin 300192, China
Wenyi Zhang: Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute Of Radiation Medicine, Chinese Academy Of Medical Sciences & Peking Union Medical College, Tianjin 300192, China

IJERPH, 2014, vol. 11, issue 10, 1-13

Abstract: Radiation safety is an integral part of targeted radionuclide therapy. The aim of this work was to study the external dose rate and retained body activity as functions of time in differentiated thyroid carcinoma patients receiving 131 I therapy. Seventy patients were stratified into two groups: the ablation group (A) and the follow-up group (FU). The patients’ external dose rate was measured, and simultaneously, their retained body radiation activity was monitored at various time points. The equations of the external dose rate and the retained body activity, described as a function of hours post administration, were fitted. Additionally, the release time for patients was calculated. The reduction in activity in the group receiving a second or subsequent treatment was more rapid than the group receiving only the initial treatment. Most important, an expeditious method was established to indirectly evaluate the retained body activity of patients by measuring the external dose rate with a portable radiation survey meter. By this method, the calculated external dose rate limits are 19.2, 8.85, 5.08 and 2.32 ?Sv·h ? 1 at 1, 1.5, 2 and 3 m, respectively, according to a patient’s released threshold level of retained body activity <400 MBq. This study is beneficial for radiation safety decision-making.

Keywords: radiation safety; differentiated thyroid carcinoma; 131 I; external dose rate; retained body activity (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2014
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