Physical, Chemical, and Immunohistochemical Investigation of the Damage to Salivary Glands in a Model of Intoxication with Aluminium Citrate

Natacha M. M. da Costa, Russell S. Correa, Ismael S. M. Júnior, Adilson J. R. Figueiredo, Kelly F. B. Vilhena, Paulo M. A. Farias-Junior, Francisco B. Teixeira, Nayana M. M. Ferreira, João B. Pereira-Júnior, Kelly Das Graças F. Dantas, Marcia C. F. da Silva, Ademir F. Silva-Junior, Sergio De M. Alves-Junior, João De Jesus V. Pinheiro and Rafael Rodrigues Lima
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Natacha M. M. da Costa: Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, 66075-900 Belém-Pará, Brazil
Russell S. Correa: Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, 66075-900 Belém-Pará, Brazil
Ismael S. M. Júnior: Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, 66075-900 Belém-Pará, Brazil
Adilson J. R. Figueiredo: Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, 66075-900 Belém-Pará, Brazil
Kelly F. B. Vilhena: Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, 66075-900 Belém-Pará, Brazil
Paulo M. A. Farias-Junior: Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, 66075-900 Belém-Pará, Brazil
Francisco B. Teixeira: Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, 66075-900 Belém-Pará, Brazil
Nayana M. M. Ferreira: Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, 66075-900 Belém-Pará, Brazil
João B. Pereira-Júnior: School of Chemistry, Institute of Exact and Natural Sciences, Federal University of Pará, 66075-900 Belém-Pará, Brazil
Kelly Das Graças F. Dantas: School of Chemistry, Institute of Exact and Natural Sciences, Federal University of Pará, 66075-900 Belém-Pará, Brazil
Marcia C. F. da Silva: Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, 66075-900 Belém-Pará, Brazil
Ademir F. Silva-Junior: Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, 66075-900 Belém-Pará, Brazil
Sergio De M. Alves-Junior: School of Dentistry, Institute of Health Sciences, Federal University of Pará, 66075-900 Belém-Pará, Brazil
João De Jesus V. Pinheiro: School of Dentistry, Institute of Health Sciences, Federal University of Pará, 66075-900 Belém-Pará, Brazil
Rafael Rodrigues Lima: Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, 66075-900 Belém-Pará, Brazil

IJERPH, 2014, vol. 11, issue 12, 1-12

Abstract: Aluminum absorption leads to deposits in several tissues. In this study, we have investigated, to our knowledge for the first time, aluminum deposition in the salivary glands in addition to the resultant cellular changes in the parotid and submandibular salivary glands in a model of chronic intoxication with aluminum citrate in rats. Aluminum deposits were observed in the parotid and submandibular glands. Immunohistochemical evaluation of cytokeratin-18 revealed a decreased expression in the parotid gland with no changes in the submandibular gland. A decreased expression of α-smooth muscle actin was observed in the myoepithelial cells of both glands. The expression of metallothionein I and II (MT-I/II), a group of metal-binding proteins, which are useful indicators for detecting physiological responses to metal exposure, was higher in both glands. In conclusion, we have shown that at a certain time and quantity of dosage, aluminum citrate promotes aluminum deposition in the parotid and submandibular glands, leads to an increased expression of MT-I/II in both the glands, damages the cytoskeleton of the myoepithelial cells in both glands, and damages the cytoskeleton of the acinar/ductal cells of the parotid glands, with the submandibular glands showing resistance to the toxicity of the latter.

Keywords: aluminum citrate; toxicology; salivary gland (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2014
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