Relationship between Obesity, Adipocytokines and Inflammatory Markers in Type 2 Diabetes: Relevance for Cardiovascular Risk Prevention

Natasa Rajkovic, Miroslava Zamaklar, Katarina Lalic, Aleksandra Jotic, Ljiljana Lukic, Tanja Milicic, Sandra Singh, Ljubica Stosic and Nebojsa M. Lalic
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Natasa Rajkovic: Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Dr. Subotica 13, Belgrade 11000, Serbia
Miroslava Zamaklar: Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Dr. Subotica 13, Belgrade 11000, Serbia
Katarina Lalic: Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Dr. Subotica 13, Belgrade 11000, Serbia
Aleksandra Jotic: Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Dr. Subotica 13, Belgrade 11000, Serbia
Ljiljana Lukic: Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Dr. Subotica 13, Belgrade 11000, Serbia
Tanja Milicic: Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Dr. Subotica 13, Belgrade 11000, Serbia
Sandra Singh: Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Dr. Subotica 13, Belgrade 11000, Serbia
Ljubica Stosic: Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Dr. Subotica 13, Belgrade 11000, Serbia
Nebojsa M. Lalic: Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Dr. Subotica 13, Belgrade 11000, Serbia

IJERPH, 2014, vol. 11, issue 4, 1-17

Abstract: This study aimed to analyse the impact of obesity in type 2 diabetes (T2D) on adipocytokines (adiponectin, leptin and resistin) and inflammatory markers (TNF-?, IL-6 and hsCRP) as cardiovascular risk factors. A cross-sectional study comparing the basal levels of adipocytokines and inflammatory markers was done in 18 obese (BMI ? 30 kg/m 2 ) (group A), 21 overweight (25 kg/m 2 ? BMI < 30 kg/m 2 ) (group B), 25 non-obese T2D patients (group C) and 15 non-obese controls (group D). The lowest levels of adiponectin and the highest levels of leptin, resistin, TNF-?, IL-6 and hsCRP were found in group A. Adiponectin levels were significantly lower, and resistin, TNF-?, and hsCRP levels were elevated in group C vs. D. However, leptin and IL-6 levels differed significantly between groups A and B, but not between groups C and D. Moreover, we found a significant negative correlation between adiponectin and TNF-?, but not with other markers, which was independent of the presence of obesity. In contrast, leptin and resistin correlated with the inflammatory markers, and this correlation was obesity-dependent. Our results suggest that obesity influences cardiovascular risk primarily through changes in leptin and resistin and less efficiently at the level of adiponectin.

Keywords: cardiovascular prevention; obesity; diabetes; adipocytokines; inflammatory markers (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2014
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