Toxicological Effects of Nickel Chloride on IgA + B Cells and sIgA, IgA, IgG, IgM in the Intestinal Mucosal Immunity in Broilers

Bangyuan Wu, Hengmin Cui, Xi Peng, Jing Fang, Zhicai Zuo, Junliang Deng and Jianying Huang
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Bangyuan Wu: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
Hengmin Cui: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
Xi Peng: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
Jing Fang: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
Zhicai Zuo: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
Junliang Deng: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
Jianying Huang: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China

IJERPH, 2014, vol. 11, issue 8, 1-18

Abstract: The objective of this study was to investigate the toxicological effects of dietary NiCl 2 on IgA + B cells and the immunoglobulins including sIgA, IgA, IgG and IgM in the small intestine and cecal tonsil of broilers by the methods of immunohistochemistry and enzyme-linked immunosorbent assay (ELISA). Two hundred and forty one-day-old avian broilers were randomly divided into four groups and fed on a control diet and three experimental diets supplemented with 300, 600, and 900 mg/kg NiCl 2 for 42 days. Compared with the control group, the IgA + B cell number and the sIgA, IgA, IgG, and IgM contents in the NiCl 2 -treated groups were significantly decreased ( p < 0.05 or p < 0.01). It was concluded that dietary NiCl 2 in the excess of 300 mg/kg had negative effects on the IgA + B cell number and the abovementioned immunoglobulin contents in the small intestine and the cecal tonsil. NiCl 2 -reduced sIgA, IgA, IgG and IgM contents is due to decrease in the population and/or the activation of B cell. The results suggest that NiCl 2 at high levels has intestinal mucosal humoral immunotoxicity in animals.

Keywords: nickel chloride; IgA + B cell; immunoglobulins; small intestine; cecal tonsil; broiler (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2014
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