Evaluation of the Relationship between 5-HTT and MAO Gene Polymorphisms, Mood and Level of Anxiety among Postmenopausal Women

Elżbieta Grochans, Anna Jurczak, Małgorzata Szkup, Agnieszka Samochowiec, Anna Włoszczak-Szubzda, Beata Karakiewicz, Anna Grzywacz, Agnieszka Brodowska and Jerzy Samochowiec
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Elżbieta Grochans: Department of Nursing, Pomeranian Medical University in Szczecin, 48 Żołnierska St., 71-210 Szczecin, Poland
Anna Jurczak: Department of Nursing, Pomeranian Medical University in Szczecin, 48 Żołnierska St., 71-210 Szczecin, Poland
Małgorzata Szkup: Department of Nursing, Pomeranian Medical University in Szczecin, 48 Żołnierska St., 71-210 Szczecin, Poland
Agnieszka Samochowiec: Department of Clinical Psychology, Institute of Psychology, University of Szczecin, 69 Krakowska St., 71-017 Szczecin, Poland
Anna Włoszczak-Szubzda: Department of Informatics and Health Statistics, Institute of Rural Health, 2 Jaczewskiego St., 20-090 Lublin, Poland
Beata Karakiewicz: Department of Public Health, Pomeranian Medical University in Szczecin, 48 Żołnierska St., 71-210 Szczecin, Poland
Anna Grzywacz: Department of Psychiatry, Pomeranian Medical University in Szczecin, 26 Broniewskiego St., 71-460 Szczecin, Poland
Agnieszka Brodowska: Department of Gynaecology and Urogynaecology, Pomeranian Medical University in Szczecin, 2 Siedlecka St., 71-010 Police, Poland
Jerzy Samochowiec: Department of Psychiatry, Pomeranian Medical University in Szczecin, 26 Broniewskiego St., 71-460 Szczecin, Poland

IJERPH, 2014, vol. 12, issue 1, 1-14

Abstract: Objective : The aim of this study was to analyze how mood and anxiety level are related to the functional genetic polymorphism in the promoter region of SLC6A4 ( 5-HTTLPR) and the 30-bp VNTR polymorphism in the MAO A promoter region. Methods : The study involved 272 postmenopausal women from Poland. The authors employed the State-Trait Anxiety Inventory for measuring levels of anxiety, the Mood Adjective Check List for measuring mood, and genetic tests. Results : Analysis did not show any statistically significant differences in the mean levels of anxiety, and mood disorders in women in relation to genotypes of the 5-HTTLPR (SLC6A4) polymorphism and the 30-bp VNTR polymorphism in the MAO A promoter region. However, these problems were more severe among women with s/s genotype. In the case of MAO A gene polymorphism, the level of anxiety was higher in women with a 4/4 genotype. Conclusions : The study did not prove the possibility of the identification of homogeneous groups of women with an elevated risk of developing anxiety and mood disorders during the post-menopausal period. Nevertheless, it showed that respondents with s/s genotype of the 44-bp polymorphism in the 5-HTT (SLC6A4) promoter region had the highest average anxiety levels both as a state and as a trait. Furthermore, the analysis of the 30-bp VNTR polymorphism in the MAO A promoter region demonstrated slight differences in anxiety levels between the women, indicating that those with a 4/4 genotype had higher severity of anxiety symptoms.

Keywords: mood disorders; postmenopause; 5HTTLPR; MAO A; anxiety (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2014
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