Residential Radon Exposure and Incidence of Childhood Lymphoma in Texas, 1995–2011

Erin C. Peckham, Michael E. Scheurer, Heather E. Danysh, Joseph Lubega, Peter H. Langlois and Philip J. Lupo
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Erin C. Peckham: Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, One Baylor Plaza, MS BCM305, Houston, TX 77030, USA
Michael E. Scheurer: Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, One Baylor Plaza, MS BCM305, Houston, TX 77030, USA
Heather E. Danysh: Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, One Baylor Plaza, MS BCM305, Houston, TX 77030, USA
Joseph Lubega: Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, One Baylor Plaza, MS BCM305, Houston, TX 77030, USA
Peter H. Langlois: Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, MC 1964, P.O. Box 149347, Austin, TX 78714-9347, USA
Philip J. Lupo: Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, One Baylor Plaza, MS BCM305, Houston, TX 77030, USA

IJERPH, 2015, vol. 12, issue 10, 1-17

Abstract: There is warranted interest in assessing the association between residential radon exposure and the risk of childhood cancer. We sought to evaluate the association between residential radon exposure and the incidence of childhood lymphoma in Texas. The Texas Cancer Registry ( n = 2147) provided case information for the period 1995–2011. Denominator data were obtained from the United States Census. Regional arithmetic mean radon concentrations were obtained from the Texas Indoor Radon Survey and linked to residence at diagnosis. Exposure was assessed categorically: ?25th percentile (reference), >25th to ?50th percentile, >50th to ?75th percentile, and >75th percentile. Negative binomial regression generated adjusted incidence rate ratios (aIRR) and 95% confidence intervals (CI). We evaluated lymphoma overall and by subtype: Hodgkin (HL; n = 1248), Non-Hodgkin excluding Burkitt (non-BL NHL; n = 658), Burkitt (BL; n = 241), and Diffuse Large B-cell (DLBCL; n = 315). There was no evidence that residential radon exposure was positively associated with lymphoma overall, HL, or BL. Areas with radon concentrations >75th percentile had a marginal increase in DLBCL incidence (aIRR = 1.73, 95% CI: 1.03–2.91). In one of the largest studies of residential radon exposure and the incidence of childhood lymphoma, we found little evidence to suggest a positive or negative association; an observation consistent with previous studies.

Keywords: childhood cancer; epidemiology; lymphoma; residential radon; Texas Cancer Registry (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2015
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