Association of Exposure to Particular Matter and Carotid Intima-Media Thickness: A Systematic Review and Meta-Analysis

Xiaole Liu, Hui Lian, Yanping Ruan, Ruijuan Liang, Xiaoyi Zhao, Michael Routledge and Zhongjie Fan
Additional contact information
Xiaole Liu: Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
Hui Lian: Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
Yanping Ruan: Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
Ruijuan Liang: Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
Xiaoyi Zhao: Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
Michael Routledge: Leeds Institute of Cardiovascular & Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK
Zhongjie Fan: Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China

IJERPH, 2015, vol. 12, issue 10, 1-17

Abstract: Background : Long time exposure to particular matter has been linked to myocardial infarction, stroke and blood pressure, but its association with atherosclerosis is not clear. This meta-analysis was aimed at assessing whether PM 2.5 and PM 10 have an effect on subclinical atherosclerosis measured by carotid intima-media thickness (CIMT). Methods : Pubmed, Ovid Medline, Embase and NICK between 1948 and 31 March 2015 were searched by combining the keywords about exposure to the outcome related words. The random-effects model was applied in computing the change of CIMT and their corresponding 95% confidence interval (95% CI). The effect of potential confounding factors was assessed by stratified analysis and the impact of traffic proximity was also estimated. Results : Among 56 identified studies, 11 articles satisfied the inclusion criteria. In overall analysis increments of 10 ?g/m 3 in PM 2.5 and PM 10 were associated with an increase of CIMT (16.79 ?m; 95% CI, 4.95–28.63 ?m and 4.13 ?m; 95% CI, ?5.79–14.04 ?m, respectively). Results shown in subgroup analysis had reference value for comparing with those of the overall analysis. The impact of traffic proximity on CIMT was uncertain. Conclusions : Exposure to PM 2.5 had a significant association with CIMT and for women the effect may be more obvious.

Keywords: air pollution; PM 2.5; PM 10; carotid intima-media thickness; subclinical atherosclerosis; meta-analysis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2015
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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