Variation in the Effect of Particulate Matter on Pulmonary Function in Schoolchildren in Western Japan and Its Relation with Interleukin-8

Masanari Watanabe, Hisashi Noma, Jun Kurai, Hiroyuki Sano, Hiroya Kitano, Rumiko Saito, Yutaka Kimura, Setsuya Aiba, Mitsuo Oshimura and Eiji Shimizu
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Masanari Watanabe: Department of Respiratory Medicine and Rheumatology, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago 683-8504, Japan
Hisashi Noma: Department of Data Science, Institute of Statistical Mathematics, 10-3 Midori-cho, Tachikawa, Tokyo 190-8562, Japan
Jun Kurai: Department of Respiratory Medicine and Rheumatology, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago 683-8504, Japan
Hiroyuki Sano: Department of Respiratory Medicine and Allergology, Faculty of Medicine, Kinki University, Ohnohigashi 377-2, Osakasayama 589-0014, Japan
Hiroya Kitano: Board of Directors, Tottori University, 36-1 Nishi-cho, Yonago 683-8504, Japan
Rumiko Saito: Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8573, Japan
Yutaka Kimura: Department of Dermatology, Graduate School of Medicine, Tohoku University, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan
Setsuya Aiba: Department of Dermatology, Graduate School of Medicine, Tohoku University, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan
Mitsuo Oshimura: Chromosome Engineering Research Center, Tottori University, 36-1 Nishi-cho, Yonago 683-8504, Japan
Eiji Shimizu: Department of Respiratory Medicine and Rheumatology, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago 683-8504, Japan

IJERPH, 2015, vol. 12, issue 11, 1-15

Abstract: This study aimed to investigate the effects of particulate matter (PM) on pulmonary function in schoolchildren, as well as the relationships of these effects with interleukin-8. Morning peak expiratory flow (PEF) was measured daily in 399 children during April–May 2012, and in 384 of these children during March–May 2013. PEF’s association with the daily levels of suspended particulate matter (SPM) and PM < 2.5 mm (PM 2.5 ) was estimated using a linear mixed model. Interleukin-8 promoter activity was assessed in THP-G8 cells stimulated by fallen PM collected at Tottori University Hospital during four periods (two in 2012 and two in 2013). An increase of 14.0 mg/m 3 in SPM led to PEF changes of ?2.16 L/min in 2012 and ?0.81 L/min in 2013, respectively. An increment of 10.7 mg/m 3 in PM 2.5 was associated with PEF changes of ?2.58 L/min in 2012 and ?0.55 L/min in 2013, respectively. These associations were only significant in 2012. Interleukin-8 promoter activity was significantly higher in both periods of 2012 than in 2013. There was a significant association between pulmonary function in schoolchildren and daily levels of SPM and PM 2.5 , but this association may differ depending on the PM’s ability to elicit interleukin-8 production.

Keywords: interlukin-8; peak expiratory flow; PM 2.5; schoolchildren; suspended particle matter (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2015
References: View complete reference list from CitEc
Citations: View citations in EconPapers (3)

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